› 4bq7

X-ray diffraction
6.6Å resolution

Crystal structure of the RGMB-Neo1 complex form 2

Released:
DOI: 10.2210/pdb4bq7/pdb
PDB entry 4bq7 coloured by chain, front view.
PDB entry 4bq7 coloured by chain, side view.
PDB entry 4bq7 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJC, Aricescu AR, Pasterkamp RJ, Siebold C
Science 341 77-80 (2013)
PMID: 23744777

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161330 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Neogenin Chains: A, B
Molecule details ›
Chains: A, B
Length: 264 amino acids
Theoretical weight: 29.22 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P97798 (Residues: 883-1133; Coverage: 17%)
Gene names: Neo1, Ngn
Sequence domains: Fibronectin type III domain
Repulsive guidance molecule B Chains: C, E
Molecule details ›
Chains: C, E
Length: 122 amino acids
Theoretical weight: 13.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NW40 (Residues: 50-168; Coverage: 30%)
Gene name: RGMB
Sequence domains: Repulsive guidance molecule (RGM) N-terminus
Repulsive guidance molecule B Chains: D, F
Molecule details ›
Chains: D, F
Length: 251 amino acids
Theoretical weight: 27.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NW40 (Residues: 169-410; Coverage: 62%)
Gene name: RGMB
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3212
Unit cell:
a: 109.69Å b: 109.69Å c: 187.93Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.256 0.254 0.28
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Structural Biology and Evolution of the TGF-β Family.
Hinck et al. (2016)
6 more

2 mentions without citation

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
Bell et al. (2013)
1 more