› 4bq9

X-ray diffraction
2.91Å resolution

Crystal structure of the FN5 and FN6 domains of NEO1, form 1

Released:
DOI: 10.2210/pdb4bq9/pdb
PDB entry 4bq9 coloured by chain, front view.
PDB entry 4bq9 coloured by chain, side view.
PDB entry 4bq9 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJC, Aricescu AR, Pasterkamp RJ, Siebold C
Science 341 77-80 (2013)
PMID: 23744777

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161329 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neogenin Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 24.08 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P97798 (Residues: 883-1083; Coverage: 14%)
Gene names: Neo1, Ngn
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 103.551Å b: 103.551Å c: 110.776Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.205 0.23
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Structural Biology and Evolution of the TGF-β Family.
Hinck et al. (2016)
6 more

3 mentions without citation

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
Bell et al. (2013)
2 more