› 4bqc

X-ray diffraction
3.2Å resolution

Crystal structure of the FN5 and FN6 domains of NEO1 bound to SOS

Released:
DOI: 10.2210/pdb4bqc/pdb
PDB entry 4bqc coloured by chain, front view.
PDB entry 4bqc coloured by chain, side view.
PDB entry 4bqc coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJC, Aricescu AR, Pasterkamp RJ, Siebold C
Science 341 77-80 (2013)
PMID: 23744777

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161329 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neogenin Chains: A, B
Molecule details ›
Chains: A, B
Length: 264 amino acids
Theoretical weight: 29.22 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P97798 (Residues: 883-1133; Coverage: 17%)
Gene names: Neo1, Ngn
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: GU4, YYJ
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2221
Unit cell:
a: 96.16Å b: 157.84Å c: 89.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.258
Expression system: Homo sapiens

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Citations

7 review citations

Structural Biology and Evolution of the TGF-β Family.
Hinck et al. (2016)
6 more

1 mention without citation

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
Bell et al. (2013)