› 4btf

X-ray diffraction
2.6Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190045 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mixed lineage kinase domain-like protein Chain: A
Molecule details ›
Chain: A
Length: 469 amino acids
Theoretical weight: 53.86 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9D2Y4 (Residues: 1-472; Coverage: 98%)
Gene name: Mlkl
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FMT 1 x FMT
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 42.4Å b: 78.3Å c: 162.938Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.256
Expression system: Spodoptera frugiperda

Quick links

Citations

237 review citations

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
Vanden Berghe et al. (2014)
236 more

37 mentions without citation

Pore formation in regulated cell death.
Flores-Romero et al. (2020)
36 more