› 4c57

X-ray diffraction
2.55Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208044 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-G-associated kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 340 amino acids
Theoretical weight: 38.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14976 (Residues: 14-351; Coverage: 26%)
Gene names: DNAJC26, GAK
Sequence domains: Protein kinase domain
Structure domains: Transferase(Phosphotransferase) domain 1
NANOBODY Chains: C, D
Molecule details ›
Chains: C, D
Length: 141 amino acids
Theoretical weight: 15.67 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand EDO 6 x EDO
Ligand FEF 2 x FEF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 75.16Å b: 86.66Å c: 83.91Å
α: 90° β: 96.44° γ: 90°
R-values:
R R work R free
0.18 0.178 0.228
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli

Quick links

Citations

12 review citations

Nanobodies and recombinant binders in cell biology.
Helma et al. (2015)
11 more

7 mentions without citation

COVID-19: Drug Targets and Potential Treatments.
Gil et al. (2020)
6 more