Function and Biology Details
Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
AMPK complex, alpha2-beta1-gamma1 variant (preferred)
PDBe Complex ID:
PDB-CPX-157057 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
5'-AMP-activated protein kinase catalytic subunit alpha-2
Molecule details ›
Chains: A, C
Length: 571 amino acids
Theoretical weight: 64.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 571 amino acids
Theoretical weight: 64.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P54646 (Residues: 1-552; Coverage: 100%)
Sequence domains:
- Protein kinase domain
- AMP-activated protein kinase, alpha subunit, autoinhibitory domain
- Adenylate sensor of SNF1-like protein kinase
5'-AMP-activated protein kinase subunit beta-1
Molecule details ›
Chains: B, D
Length: 286 amino acids
Theoretical weight: 32.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 286 amino acids
Theoretical weight: 32.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9Y478 (Residues: 1-270; Coverage: 100%)
Sequence domains:
5'-AMP-activated protein kinase subunit gamma-1
Molecule details ›
Chains: E, F
Length: 331 amino acids
Theoretical weight: 37.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: CBS domain
Length: 331 amino acids
Theoretical weight: 37.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P54619 (Residues: 1-331; Coverage: 100%)
Sequence domains: CBS domain
