Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- WD40/YVTN repeat-like-containing domain superfamily
- CULT domain
- Lon protease, N-terminal domain
- Yippee/Mis18/Cereblon
- PUA-like superfamily
- Lon protease, N-terminal domain superfamily
- WD40-repeat-containing domain superfamily
- Cleavage/polyadenylation specificity factor, A subunit, C-terminal
1 more domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143225 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA damage-binding protein 1
Molecule details ›
Chain: A
Length: 1158 amino acids
Theoretical weight: 129.49 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Structure domains:
Length: 1158 amino acids
Theoretical weight: 129.49 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q16531 (Residues: 1-1140; Coverage: 100%)
Sequence domains:
Structure domains:
Protein cereblon
Molecule details ›
Chain: B
Length: 469 amino acids
Theoretical weight: 54.21 KDa
Source organism: Gallus gallus
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 469 amino acids
Theoretical weight: 54.21 KDa
Source organism: Gallus gallus
Expression system: Trichoplusia ni
UniProt:
- Canonical: P0CF65 (Residues: 1-445; Coverage: 100%)
Sequence domains:
- ATP-dependent protease La (LON) substrate-binding domain
- Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
