› 4cn0

X-ray diffraction
1.75Å resolution

An intertwined homodimer of the PDZ homology domain of AHNAK2

Released:
DOI: 10.2210/pdb4cn0/pdb
PDB entry 4cn0 coloured by chain, front view.
PDB entry 4cn0 coloured by chain, side view.
PDB entry 4cn0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping.
Han H, Kursula P
J Biol Chem 289 14121-31 (2014)
PMID: 24675079

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184867 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein AHNAK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 97 amino acids
Theoretical weight: 10.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IVF2 (Residues: 108-203; Coverage: 2%)
Gene names: AHNAK2, C14orf78, KIAA2019

Ligands and Environments

2 bound ligands:
Ligand PG4 3 x PG4
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P3121
Unit cell:
a: 81.73Å b: 81.73Å c: 65.31Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.18 0.206
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

AHNAK: the giant jack of all trades.
Davis et al. (2014)
3 more

2 mentions without citation

Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping.
Han et al. (2014)
1 more