Function and Biology Details
Reactions catalysed:
Testosterone + NAD(+) = androstenedione + NADH
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
NADPH + a quinone = NADP(+) + a quinol
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185397 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
(3R)-3-hydroxyacyl-CoA dehydrogenase
Molecule details ›
Chains: A, D, E, H, I, L, M, P
Length: 261 amino acids
Theoretical weight: 27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain
Length: 261 amino acids
Theoretical weight: 27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
Q92506 (Residues: 1-261; Coverage: 100%)
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain
3-oxoacyl-[acyl-carrier-protein] reductase
Molecule details ›
Chains: B, C, F, G, J, K, N, O
Length: 244 amino acids
Theoretical weight: 26.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain
Length: 244 amino acids
Theoretical weight: 26.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical: Q8N4T8 (Residues: 1-237; Coverage: 100%)
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain
