› 4cy3

X-ray diffraction
1.4Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107435 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein will die slowly Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 34.67 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9V3J8 (Residues: 50-361; Coverage: 86%)
Gene names: CG17437, l(1)3Ad, l(1)zw8, wds
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
PEHE domain-containing protein Chain: D
Molecule details ›
Chain: D
Length: 16 amino acids
Theoretical weight: 1.77 KDa
Source organism: Drosophila melanogaster
Expression system: Not provided
UniProt:
  • Canonical: A4V2Z1 (Residues: 714-729; Coverage: 1%)
Gene names: CG4699, Dmel\CG4699, Dmel_CG4699, E(nos), NSL1, Nsl1, l(3)06536, l(3)S009413, nsl1, wah

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2221
Unit cell:
a: 78.74Å b: 98.85Å c: 80.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.179 0.19
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

9 review citations

Moonlighting with WDR5: A Cellular Multitasker.
Guarnaccia et al. (2018)
8 more

2 mentions without citation

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.
Dias et al. (2014)
1 more