› 4d7b

X-ray diffraction
1.15Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 128 amino acids
Theoretical weight: 13.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand TCW 2 x TCW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21212
Unit cell:
a: 84.112Å b: 43.807Å c: 65.852Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.171 0.201
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review.
Ruberg et al. (2019)
33 more

7 mentions without citation

Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms.
Giorgetti et al. (2018)
6 more