Function and Biology Details
Reactions catalysed:
Converts human Glu-plasminogen to plasmin by cleaving the 560-Arg-|-Val-561 peptide bond that is also hydrolyzed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins.
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Plasminogen activator and Angiostatin (preferred)
PDBe Complex ID:
PDB-CPX-133232 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Plasminogen activator
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 33.28 KDa
Source organism: Yersinia pestis
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Omptin family
Structure domains: OMPT-like
Length: 297 amino acids
Theoretical weight: 33.28 KDa
Source organism: Yersinia pestis
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P17811 (Residues: 25-312; Coverage: 99%)
Sequence domains: Omptin family
Structure domains: OMPT-like
Plasmin light chain B
Molecule details ›
Chain: F
Length: 11 amino acids
Theoretical weight: 1.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P00747 (Residues: 576-585; Coverage: 1%)
