› 4dou

X-ray diffraction
2Å resolution

Crystal Structure of a Single-chain Trimer of Human Adiponectin Globular Domain

Released:
DOI: 10.2210/pdb4dou/pdb
PDB entry 4dou coloured by chain, front view.
PDB entry 4dou coloured by chain, side view.
PDB entry 4dou coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a single-chain trimer of human adiponectin globular domain.
Min X, Lemon B, Tang J, Liu Q, Zhang R, Walker N, Li Y, Wang Z
FEBS Lett 586 912-7 (2012)
PMID: 22449980

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adiponectin Chain: A
Molecule details ›
Chain: A
Length: 442 amino acids
Theoretical weight: 51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15848 (Residues: 104-244; Coverage: 63%)
Gene names: ACDC, ACRP30, ADIPOQ, APM1, GBP28
Sequence domains: C1q domain
Structure domains: Jelly Rolls

Ligands and Environments

4 bound ligands:
Ligand CA 3 x CA
Ligand NA 1 x NA
Ligand GOL 1 x GOL
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P1
Unit cell:
a: 48.31Å b: 49.63Å c: 50.46Å
α: 117.23° β: 101.68° γ: 105.31°
R-values:
R R work R free
0.203 0.2 0.257
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Adiponectin: Probe of the molecular paradigm associating diabetes and obesity.
Ghoshal et al. (2015)
6 more

13 mentions without citation

Systematic detection of internal symmetry in proteins using CE-Symm.
Myers-Turnbull et al. (2014)
12 more