› 4dx2

X-ray diffraction
2.95Å resolution

Crystal structure of the human TRPV4 ankyrin repeat domain

Released:
DOI: 10.2210/pdb4dx2/pdb
PDB entry 4dx2 coloured by chain, front view.
PDB entry 4dx2 coloured by chain, side view.
PDB entry 4dx2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.
Inada H, Procko E, Sotomayor M, Gaudet R
Biochemistry 51 6195-206 (2012)
PMID: 22702953

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190741 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HBA0 (Residues: 148-397; Coverage: 29%)
Gene names: TRPV4, VRL2, VROAC
Sequence domains: Ankyrin repeat
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

3 bound ligands:
Ligand BGC 1 x BGC
Ligand ATP 1 x ATP
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P3221
Unit cell:
a: 147.89Å b: 147.89Å c: 93.901Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.177 0.22
Expression system: Escherichia coli

Quick links

Citations

19 review citations

TRPV4: Molecular Conductor of a Diverse Orchestra.
White et al. (2016)
18 more

7 mentions without citation

Structure of thermally activated TRP channels.
Cohen et al. (2014)
6 more