4dxr

X-ray diffraction
2.32Å resolution

Human SUN2-KASH1 complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-185522 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SUN domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 22.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UH99 (Residues: 522-717; Coverage: 27%)
Gene names: FRIGG, KIAA0668, RAB5IP, SUN2, UNC84B
Sequence domains: Sad1 / UNC-like C-terminal
Structure domains: Galactose-binding domain-like
Nesprin-1 Chain: B
Molecule details ›
Chain: B
Length: 35 amino acids
Theoretical weight: 3.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NF91 (Residues: 8769-8797; Coverage: 0%)
Gene names: C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1, SYNE1
Sequence domains: Nuclear envelope localisation domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: R32
Unit cell:
a: 79.641Å b: 79.641Å c: 256.409Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.171 0.227
Expression system: Escherichia coli