› 4e3c

X-ray diffraction
3.98Å resolution

X-ray crystal structure of human IKK2 in an active conformation

Released:
DOI: 10.2210/pdb4e3c/pdb
PDB entry 4e3c coloured by chain, front view.
PDB entry 4e3c coloured by chain, side view.
PDB entry 4e3c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of human IKK2 in an active conformation
Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Hoffmann A, Verma IV, Ghosh G, Huaford T
PLoS Biol. (2013)

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inhibitor of nuclear factor kappa-B kinase subunit beta Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 669 amino acids
Theoretical weight: 77.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14920 (Residues: 11-669; Coverage: 87%)
Gene names: IKBKB, IKKB
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4122
Unit cell:
a: 170.81Å b: 170.81Å c: 509.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.267 0.267 0.299
Expression system: Spodoptera frugiperda

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