› 4e74

X-ray diffraction
1.58Å resolution

Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A

Released:
DOI: 10.2210/pdb4e74/pdb
PDB entry 4e74 coloured by chain, front view.
PDB entry 4e74 coloured by chain, side view.
PDB entry 4e74 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guan X, Wang H, Tempel W, Dong A, Tong Y, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190786 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plexin-A4 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HCM2 (Residues: 1488-1603; Coverage: 6%)
Gene names: KIAA1550, PLXNA4, PLXNA4A, PLXNA4B, UNQ2820/PRO34003
Sequence domains: Plexin cytoplasmic RhoGTPase-binding domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand UNX 11 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41212
Unit cell:
a: 49.79Å b: 49.79Å c: 124.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.203 0.219
Expression system: Escherichia coli

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