› 4ej4

X-ray diffraction
3.4Å resolution

Structure of the delta opioid receptor bound to naltrindole

Released:
DOI: 10.2210/pdb4ej4/pdb
PDB entry 4ej4 coloured by chain, front view.
PDB entry 4ej4 coloured by chain, side view.
PDB entry 4ej4 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the δ-opioid receptor bound to naltrindole.
Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK
Nature 485 400-4 (2012)
PMID: 22596164

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Delta-type opioid receptor; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 461 amino acids
Theoretical weight: 51.63 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P32300 (Residues: 36-244, 251-342; Coverage: 81%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
Gene names: E, Oprd1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EJ4 1 x EJ4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B, null
Spacegroup: P3121
Unit cell:
a: 73.278Å b: 73.278Å c: 266.653Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.252 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

125 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
124 more

89 mentions without citation

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.
Stevens et al. (2013)
88 more