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Crystal structure of rat carnitine palmitoyltransferase 2 in complex with 1-[(R)-2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-piperidin-1-yl]-2-phenoxy-ethanone

Source organism: Rattus norvegicus
Biochemical function: acyltransferase activity
Biological process: positive regulation of cold-induced thermogenesis
Cellular component: membrane

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EC 2.3.1.21: Carnitine O-palmitoyltransferase

Reaction catalysed:
Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
Systematic name:
Palmitoyl-CoA:L-carnitine O-palmitoyltransferase
Alternative Name(s):
  • Acylcarnitine transferase
  • CPT
  • CPT I (outer membrane carnitine palmitoyl transferase)
  • CPT-A
  • CPT-B
  • CPTi
  • CPTo
  • Carnitine palmitoyltransferase
  • Carnitine palmitoyltransferase I
  • Carnitine palmitoyltransferase II
  • Carnitine palmitoyltransferase-A
  • L-carnitine palmitoyltransferase
  • Outer malonyl-CoA inhibitable carnitine palmitoyltransferase
  • Palmitoylcarnitine transferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00755
Domain description: Choline/Carnitine o-acyltransferase
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
The deposited structure of PDB entry 4eyw contains 2 copies of Pfam domain PF00755 (Choline/Carnitine o-acyltransferase) in Carnitine O-palmitoyltransferase 2, mitochondrial. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000542
Domain description: Acyltransferase ChoActase/COT/CPT
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
IPR023213
Domain description: Chloramphenicol acetyltransferase-like domain superfamily
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
IPR042231
Domain description: Choline/Carnitine o-acyltransferase, domain 2
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
IPR039551
Domain description: Choline/carnitine acyltransferase domain
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
IPR042572
Domain description: Carnitine o-acyltransferase, N-terminal
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial

Structure domains

CATH CATH domains
3.30.559.70
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chloramphenicol Acetyltransferase
Homology: Choline/Carnitine o-acyltransferase, domain 2
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
The deposited structure of PDB entry 4eyw contains 2 copies of CATH domain 3.30.559.70 (Chloramphenicol Acetyltransferase) in Carnitine O-palmitoyltransferase 2, mitochondrial. Showing 1 copy in chain B.
3.30.559.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chloramphenicol Acetyltransferase
Homology: Chloramphenicol acetyltransferase-like domain
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
The deposited structure of PDB entry 4eyw contains 2 copies of CATH domain 3.30.559.10 (Chloramphenicol Acetyltransferase) in Carnitine O-palmitoyltransferase 2, mitochondrial. Showing 1 copy in chain B.
1.20.1280.180
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Monooxygenase
Homology: Monooxygenase
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
The deposited structure of PDB entry 4eyw contains 2 copies of CATH domain 1.20.1280.180 (Monooxygenase) in Carnitine O-palmitoyltransferase 2, mitochondrial. Showing 1 copy in chain B.

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