› 4fqj

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207906 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 33.24 KDa
Source organism: Influenza B virus (B/reassortant/NYMC BX-21A(Lee/1940 x Florida/04/2006))
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: I0B7N4 (Residues: 46-343; Coverage: 51%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
antibody CR8071 light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.11 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Structure domains: Immunoglobulins
antibody CR8071 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 234 amino acids
Theoretical weight: 25.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 45.57Å b: 111.93Å c: 168.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.265
Expression system: Spodoptera frugiperda

Quick links

Citations

120 review citations

Advances in the development of influenza virus vaccines.
Krammer et al. (2015)
119 more

12 mentions without citation

A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.
Wu et al. (2017)
11 more