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Crystal structure of HLA-DM bound to HLA-DR1

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: antigen processing and presentation
Cellular component: MHC class II protein complex

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
The deposited structure of PDB entry 4fqx contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class II histocompatibility antigen, DM alpha chain. Showing 1 copy in chain A [auth C].
The deposited structure of PDB entry 4fqx contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class II histocompatibility antigen, DM beta chain. Showing 1 copy in chain B [auth D].
The deposited structure of PDB entry 4fqx contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class II histocompatibility antigen, DR alpha chain. Showing 1 copy in chain D [auth A].
The deposited structure of PDB entry 4fqx contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class II histocompatibility antigen, DRB1 beta chain. Showing 1 copy in chain E [auth B].

PF00969
Domain description: Class II histocompatibility antigen, beta domain
Occurring in:
  1. HLA class II histocompatibility antigen, DRB1 beta chain
  2. HLA class II histocompatibility antigen, DM beta chain
The deposited structure of PDB entry 4fqx contains 1 copy of Pfam domain PF00969 (Class II histocompatibility antigen, beta domain) in HLA class II histocompatibility antigen, DM beta chain. Showing 1 copy in chain B [auth D].
The deposited structure of PDB entry 4fqx contains 1 copy of Pfam domain PF00969 (Class II histocompatibility antigen, beta domain) in HLA class II histocompatibility antigen, DRB1 beta chain. Showing 1 copy in chain E [auth B].

PF00993
Domain description: Class II histocompatibility antigen, alpha domain
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DM alpha chain
The deposited structure of PDB entry 4fqx contains 1 copy of Pfam domain PF00993 (Class II histocompatibility antigen, alpha domain) in HLA class II histocompatibility antigen, DM alpha chain. Showing 1 copy in chain A [auth C].
The deposited structure of PDB entry 4fqx contains 1 copy of Pfam domain PF00993 (Class II histocompatibility antigen, alpha domain) in HLA class II histocompatibility antigen, DR alpha chain. Showing 1 copy in chain D [auth A].

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
IPR001003
Domain description: MHC class II, alpha chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DM alpha chain
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
IPR014745
Domain description: MHC class II, alpha/beta chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
IPR000353
Domain description: MHC class II, beta chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DRB1 beta chain
  2. HLA class II histocompatibility antigen, DM beta chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
The deposited structure of PDB entry 4fqx contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class II histocompatibility antigen, DM alpha chain. Showing 1 copy in chain A [auth C].
The deposited structure of PDB entry 4fqx contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class II histocompatibility antigen, DM beta chain. Showing 1 copy in chain B [auth D].
The deposited structure of PDB entry 4fqx contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class II histocompatibility antigen, DR alpha chain. Showing 1 copy in chain D [auth A].
The deposited structure of PDB entry 4fqx contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class II histocompatibility antigen, DRB1 beta chain. Showing 1 copy in chain E [auth B].
3.10.320.10
Class: Alpha Beta
Architecture: Roll
Topology: Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Homology: Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
The deposited structure of PDB entry 4fqx contains 1 copy of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DM alpha chain. Showing 1 copy in chain A [auth C].
The deposited structure of PDB entry 4fqx contains 1 copy of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DM beta chain. Showing 1 copy in chain B [auth D].
The deposited structure of PDB entry 4fqx contains 1 copy of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DR alpha chain. Showing 1 copy in chain D [auth A].
The deposited structure of PDB entry 4fqx contains 1 copy of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DRB1 beta chain. Showing 1 copy in chain E [auth B].

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