› 4frw

X-ray diffraction
3.5Å resolution

Crystal structure of human nectin-4 extracellular fragment D1-D2

Released:
DOI: 10.2210/pdb4frw/pdb
PDB entry 4frw coloured by chain, front view.
PDB entry 4frw coloured by chain, side view.
PDB entry 4frw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Nectin ectodomain structures reveal a canonical adhesive interface.
Harrison OJ, Vendome J, Brasch J, Jin X, Hong S, Katsamba PS, Ahlsen G, Troyanovsky RB, Troyanovsky SM, Honig B, Shapiro L
Nat Struct Mol Biol 19 906-15 (2012)
PMID: 22902367

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188651 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Processed poliovirus receptor-related protein 4 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 218 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96NY8 (Residues: 32-243; Coverage: 44%)
Gene names: LNIR, NECTIN4, PRR4, PVRL4
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2221
Unit cell:
a: 85.971Å b: 142.809Å c: 341.802Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.257 0.29
Expression system: Homo sapiens

Quick links

Citations

16 review citations

Mechanobiology of collective cell behaviours.
Ladoux et al. (2017)
15 more

9 mentions without citation

Connections matter--how viruses use cell–cell adhesion components.
Mateo et al. (2015)
8 more