› 4fs6

X-ray diffraction
1.3Å resolution

Crystal structure of the Z-DNA hexamer CGCGCG at 500 mM CaCl2

Released:
DOI: 10.2210/pdb4fs6/pdb
PDB entry 4fs6 coloured by chain, front view.
PDB entry 4fs6 coloured by chain, side view.
PDB entry 4fs6 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Direct interactions between Z-DNA and alkaline earth cations, discovered in the presence of high concentrations of MgCl2 and CaCl2.
Chatake T, Sunami T
J Inorg Biochem 124 15-25 (2013)
PMID: 23578858

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117513 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CA 5 x CA
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P3221
Unit cell:
a: 18.461Å b: 18.461Å c: 71.463Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.19 0.23
Expression system: Not provided

Quick links

Citations

2 review citations

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer.
Vongsutilers et al. (2018)
1 more

2 mentions without citation

Dual conformational recognition by Z-DNA binding protein is important for the B-Z transition process.
Park et al. (2020)
1 more