› 4gfx

X-ray diffraction
1.6Å resolution

Crystal structure of the N-terminal domain of TXNIP

Released:
DOI: 10.2210/pdb4gfx/pdb
PDB entry 4gfx coloured by chain, front view.
PDB entry 4gfx coloured by chain, side view.
PDB entry 4gfx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein.
Hwang J, Suh HW, Jeon YH, Hwang E, Nguyen LT, Yeom J, Lee SG, Lee C, Kim KJ, Kang BS, Jeong JO, Oh TK, Choi I, Lee JO, Kim MH
Nat Commun 5 2958 (2014)
PMID: 24389582

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 151 amino acids
Theoretical weight: 17.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H3M7 (Residues: 4-154; Coverage: 39%)
Gene names: TXNIP, VDUP1
Sequence domains: Arrestin (or S-antigen), N-terminal domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 37.431Å b: 56.621Å c: 67.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.227
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Biological and physiological role of reactive oxygen species--the good, the bad and the ugly.
Zuo et al. (2015)
26 more

5 mentions without citation

The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.
Peterson et al. (2017)
4 more