› 4glp

X-ray diffraction
4Å resolution

The crystal structure of soluble human CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.

Released:
DOI: 10.2210/pdb4glp/pdb
PDB entry 4glp coloured by chain, front view.
PDB entry 4glp coloured by chain, side view.
PDB entry 4glp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.
Kelley SL, Lukk T, Nair SK, Tapping RI
J Immunol 190 1304-11 (2013)
PMID: 23264655

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Monocyte differentiation antigen CD14, membrane-bound form Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 33.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08571 (Residues: 26-335; Coverage: 87%)
Gene name: CD14
Sequence domains: Leucine Rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P3221
Unit cell:
a: 147.52Å b: 147.52Å c: 44.07Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.285 0.283 0.321
Expression system: Homo sapiens

Quick links

Citations

16 review citations

Recognition of lipopolysaccharide pattern by TLR4 complexes.
Park et al. (2013)
15 more

14 mentions without citation

Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo.
Martin et al. (2015)
13 more