› 4gos

X-ray diffraction
1.59Å resolution

Crystal structure of human B7-H4 IgV-like domain

Released:
DOI: 10.2210/pdb4gos/pdb
PDB entry 4gos coloured by chain, front view.
PDB entry 4gos coloured by chain, side view.
PDB entry 4gos coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and cancer immunotherapy of the B7 family member B7x.
Jeon H, Vigdorovich V, Garrett-Thomson SC, Janakiram M, Ramagopal UA, Abadi YM, Lee JS, Scandiuzzi L, Ohaegbulam KC, Chinai JM, Zhao R, Yao Y, Mao Y, Sparano JA, Almo SC, Zang X
Cell Rep 9 1089-98 (2014)
PMID: 25437562

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182306 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
V-set domain-containing T-cell activation inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 13.72 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q7Z7D3 (Residues: 30-148; Coverage: 46%)
Gene names: B7H4, UNQ659/PRO1291, VTCN1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P43212
Unit cell:
a: 46.5Å b: 46.5Å c: 115.77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.192
Expression system: Drosophila melanogaster

Quick links

Citations

11 review citations

Combination cancer immunotherapies tailored to the tumour microenvironment.
Smyth et al. (2016)
10 more

9 mentions without citation

The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3.
Janakiram et al. (2017)
8 more