› 4gt4

X-ray diffraction
2.41Å resolution

Structure of unliganded, inactive Ror2 kinase domain

Released:
DOI: 10.2210/pdb4gt4/pdb
PDB entry 4gt4 coloured by chain, front view.
PDB entry 4gt4 coloured by chain, side view.
PDB entry 4gt4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family.
Artim SC, Mendrola JM, Lemmon MA
Biochem J 448 213-20 (2012)
PMID: 22992069

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169652 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase transmembrane receptor ROR2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 308 amino acids
Theoretical weight: 35.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q01974 (Residues: 452-753; Coverage: 33%)
Gene names: NTRKR2, ROR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NO3 4 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2221
Unit cell:
a: 102.834Å b: 112.918Å c: 114.759Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.205
Expression system: Spodoptera frugiperda

Quick links

Citations

11 review citations

Insulin resistance and cancer: the role of insulin and IGFs.
Djiogue et al. (2013)
10 more

9 mentions without citation

Receptor tyrosine kinases with intracellular pseudokinase domains.
Mendrola et al. (2013)
8 more