› 4gv1

X-ray diffraction
1.49Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152081 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAC-alpha serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 39.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31749 (Residues: 144-480; Coverage: 70%)
Gene names: AKT1, PKB, RAC
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 0XZ 1 x 0XZ
Ligand GOL 4 x GOL
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 46.852Å b: 58.556Å c: 150.472Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.21
Expression system: Spodoptera frugiperda

Quick links

Citations

20 review citations

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway.
Polivka et al. (2014)
19 more

78 mentions without citation

Computer-Aided Identification of Kinase-Targeted Small Molecules for Cancer: A Review on AKT Protein.
Primavera et al. (2023)
77 more