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Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.

X-ray diffraction
1.43Å resolution
PDB entry 4h30 coloured by chain, front view.
PDB entry 4h30 coloured by chain, side view.
PDB entry 4h30 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Macrophage metalloelastase
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Multimeric state: homo dimer
Accessible surface area: 15064.83 Å2
Buried surface area: 4294.12 Å2
Dissociation area: 1,012.4 Å2
Dissociation energy (ΔGdiss): 20.13 kcal/mol
Dissociation entropy (TΔSdiss): 12.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-153975

Macromolecules

Macrophage metalloelastase
Chains: A, B
Length: 159 amino acids
Theoretical weight: 17.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P39900 (Residues: 106-263; Coverage: 35%)
Gene names: HME, MMP12
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
Macrophage metalloelastase in PDB entry 4h30, assembly 1, front view.
Macrophage metalloelastase in PDB entry 4h30, assembly 1, side view.
Macrophage metalloelastase in PDB entry 4h30, assembly 1, top view.
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