› 4h8s

X-ray diffraction
3.5Å resolution

Crystal structure of human APPL2BARPH domain

Released:
DOI: 10.2210/pdb4h8s/pdb
PDB entry 4h8s coloured by chain, front view.
PDB entry 4h8s coloured by chain, side view.
PDB entry 4h8s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase.
King GJ, Stöckli J, Hu SH, Winnen B, Duprez WG, Meoli CC, Junutula JR, Jarrott RJ, James DE, Whitten AE, Martin JL
J Biol Chem 287 40996-1006 (2012)
PMID: 23055524

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185517 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DCC-interacting protein 13-beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 407 amino acids
Theoretical weight: 46.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NEU8 (Residues: 2-384; Coverage: 58%)
Gene names: APPL2, DIP13B
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 97.96Å b: 208.013Å c: 218.359Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.256
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Molecular complexes that direct rhodopsin transport to primary cilia.
Wang et al. (2014)
7 more

3 mentions without citation

Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase.
King et al. (2012)
2 more