› 4hir

Solution NMR

SOLUTION STRUCTURE OF RECOMBINANT HIRUDIN AND THE LYS-47 (RIGHT ARROW) GLU MUTANT. A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY

Released:
DOI: 10.2210/pdb4hir/pdb
PDB entry 4hir coloured by chain, ensemble of 32 models, front view.
PDB entry 4hir coloured by chain, ensemble of 32 models, side view.
PDB entry 4hir coloured by chain, ensemble of 32 models, top view.
Source organism: Hirudo medicinalis
Primary publication:
Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.
Folkers PJ, Clore GM, Driscoll PC, Dodt J, Köhler S, Gronenborn AM
Biochemistry 28 2601-17 (1989)
PMID: 2567183

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hirudin variant-1 Chain: A
Molecule details ›
Chain: A
Length: 65 amino acids
Theoretical weight: 6.97 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P01050 (Residues: 1-65; Coverage: 100%)
Sequence domains: Hirudin
Structure domains: Thrombin Inhibitor (Hirudin), subunit I

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

14 review citations

Intrinsically disordered proteins in human diseases: introducing the D2 concept.
Uversky et al. (2008)
13 more

2 mentions without citation

Some remarks on protein attribute prediction and pseudo amino acid composition.
Chou KC. (2011)
1 more