› 4hj0

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211274 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Gastric inhibitory polypeptide receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 136 amino acids
Theoretical weight: 15.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48546 (Residues: 24-138; Coverage: 26%)
Gene name: GIPR
Sequence domains: Hormone receptor domain
Structure domains: GPCR, family 2, extracellular hormone receptor domain
Gipg013 Fab, Antagonizing antibody to the GIP Receptor, Heavy chain Chains: C, P
Molecule details ›
Chains: C, P
Length: 227 amino acids
Theoretical weight: 23.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Gipg013 Fab, Antagonizing antibody to the GIP Receptor, Light chain Chains: D, Q
Molecule details ›
Chains: D, Q
Length: 215 amino acids
Theoretical weight: 22.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P21
Unit cell:
a: 48.266Å b: 109.85Å c: 105.935Å
α: 90° β: 97.76° γ: 90°
R-values:
R R work R free
0.26 0.255 0.311
Expression systems:
  • Escherichia coli
  • Homo sapiens

Quick links

Citations

11 review citations

Opportunities for therapeutic antibodies directed at G-protein-coupled receptors.
Hutchings et al. (2017)
10 more

6 mentions without citation

Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors.
Culhane et al. (2015)
5 more