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Crystal structure of an MMP twin carboxylate based inhibitor LC20 in complex with the MMP-9 catalytic domain

X-ray diffraction
1.94Å resolution
PDB entry 4hma coloured by chain, front view.
PDB entry 4hma coloured by chain, side view.
PDB entry 4hma coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 67 kDa matrix metalloproteinase-9
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Multimeric state: homo dimer
Accessible surface area: 16926.8 Å2
Buried surface area: 4601.79 Å2
Dissociation area: 735.36 Å2
Dissociation energy (ΔGdiss): 9.1 kcal/mol
Dissociation entropy (TΔSdiss): 12.13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-147089

Macromolecules

67 kDa matrix metalloproteinase-9
Chains: A, B
Length: 160 amino acids
Theoretical weight: 17.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14780 (Residues: 110-444; Coverage: 23%)
Gene names: CLG4B, MMP9
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
67 kDa matrix metalloproteinase-9 in PDB entry 4hma, assembly 1, front view.
67 kDa matrix metalloproteinase-9 in PDB entry 4hma, assembly 1, side view.
67 kDa matrix metalloproteinase-9 in PDB entry 4hma, assembly 1, top view.
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