› 4hnf

X-ray diffraction
2.07Å resolution

Crystal structure of ck1d in complex with pf4800567

Released:
DOI: 10.2210/pdb4hnf/pdb
PDB entry 4hnf coloured by chain, front view.
PDB entry 4hnf coloured by chain, side view.
PDB entry 4hnf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.
Long AM, Zhao H, Huang X
J Med Chem 55 10307-11 (2012)
PMID: 23106386

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-155796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 34.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 16W 2 x 16W
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2
Unit cell:
a: 171.217Å b: 48.109Å c: 80.467Å
α: 90° β: 110.67° γ: 90°
R-values:
R R work R free
0.241 0.241 0.274
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Targeting Casein Kinase 1 (CK1) in Hematological Cancers.
Janovská et al. (2020)
4 more

6 mentions without citation

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.
Knippschild et al. (2014)
5 more