› 4hni

X-ray diffraction
2.74Å resolution

crystal structure of ck1e in complex with PF4800567

Released:
DOI: 10.2210/pdb4hni/pdb
PDB entry 4hni coloured by chain, front view.
PDB entry 4hni coloured by chain, side view.
PDB entry 4hni coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.
Long AM, Zhao H, Huang X
J Med Chem 55 10307-11 (2012)
PMID: 23106386

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform epsilon Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 34.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49674 (Residues: 1-294; Coverage: 71%)
Gene name: CSNK1E
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 16W 2 x 16W
Ligand SO4 9 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P43212
Unit cell:
a: 111.108Å b: 111.108Å c: 155.426Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.273
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε.
Yang et al. (2017)
3 more

6 mentions without citation

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.
Knippschild et al. (2014)
5 more