› 4hok

X-ray diffraction
2.77Å resolution

crystal structure of apo ck1e

Released:
DOI: 10.2210/pdb4hok/pdb
PDB entry 4hok coloured by chain, front view.
PDB entry 4hok coloured by chain, side view.
PDB entry 4hok coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.
Long AM, Zhao H, Huang X
J Med Chem 55 10307-11 (2012)
PMID: 23106386

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-155980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform epsilon Chains: A, C, E, G, I, K, M, O, Q, S, U, W
Molecule details ›
Chains: A, C, E, G, I, K, M, O, Q, S, U, W
Length: 296 amino acids
Theoretical weight: 34.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49674 (Residues: 1-294; Coverage: 71%)
Gene name: CSNK1E
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 12 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2
Unit cell:
a: 180.361Å b: 142.496Å c: 232.462Å
α: 90° β: 108.57° γ: 90°
R-values:
R R work R free
0.241 0.241 0.262
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Targeting Casein Kinase 1 (CK1) in Hematological Cancers.
Janovská et al. (2020)
4 more

4 mentions without citation

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.
Knippschild et al. (2014)
3 more