4htj

X-ray diffraction
2.01Å resolution

Crystallographic structure of the membrane-proximal ectodomain of the human receptor-type protein-tyrosine phosphatase phogrin at pH 4.6

Released:
Source organism: Homo sapiens
Primary publication:
X-ray structure of the mature ectodomain of phogrin.
J Struct Funct Genomics 16 1-9 (2015)
PMID: 25421040

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187816 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IA-2beta60 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 10.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92932 (Residues: 501-599; Coverage: 10%)
Gene names: KIAA0387, PTPRN2
Sequence domains: Protein-tyrosine phosphatase receptor IA-2
Structure domains: Protein-tyrosine phosphatase receptor IA-2 ectodomain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P6122
Unit cell:
a: 54.742Å b: 54.742Å c: 149.147Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.238
Expression system: Escherichia coli