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Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor

Source organism: Escherichia coli K-12
Biochemical function: ATP binding
Biological process: threonyl-tRNA aminoacylation
Cellular component: cytoplasm

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EC 6.1.1.3: Threonine--tRNA ligase

Reaction catalysed:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)
Systematic name:
L-threonine:tRNA(Thr) ligase (AMP-forming)
Alternative Name(s):
  • TRS
  • Threonine translase
  • Threonine-transfer ribonucleate synthetase
  • Threonyl ribonucleic synthetase
  • Threonyl-tRNA synthetase
  • Threonyl-transfer RNA synthetase
  • Threonyl-transfer ribonucleate synthetase
  • Threonyl-transfer ribonucleic acid synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03129
Domain description: Anticodon binding domain
Occurring in:
  1. Threonine--tRNA ligase
The deposited structure of PDB entry 4hwr contains 2 copies of Pfam domain PF03129 (Anticodon binding domain) in Threonine--tRNA ligase. Showing 1 copy in chain A.

PF00587
Domain description: tRNA synthetase class II core domain (G, H, P, S and T)
Occurring in:
  1. Threonine--tRNA ligase
The deposited structure of PDB entry 4hwr contains 2 copies of Pfam domain PF00587 (tRNA synthetase class II core domain (G, H, P, S and T)) in Threonine--tRNA ligase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002320
Domain description: Threonine-tRNA ligase, class IIa
Occurring in:
  1. Threonine--tRNA ligase
IPR045864
Domain description: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
  1. Threonine--tRNA ligase
IPR004154
Domain description: Anticodon-binding
Occurring in:
  1. Threonine--tRNA ligase
IPR047246
Domain description: Threonine-tRNA ligase, class IIa, anticodon-binding domain
Occurring in:
  1. Threonine--tRNA ligase
IPR036621
Domain description: Anticodon-binding domain superfamily
Occurring in:
  1. Threonine--tRNA ligase
IPR002314
Domain description: Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Occurring in:
  1. Threonine--tRNA ligase
IPR006195
Domain description: Aminoacyl-tRNA synthetase, class II
Occurring in:
  1. Threonine--tRNA ligase
IPR033728
Domain description: Threonine-tRNA ligase catalytic core domain
Occurring in:
  1. Threonine--tRNA ligase

Structure domains

CATH CATH domains
3.40.50.800
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Anticodon-binding domain
Occurring in:
  1. Threonine--tRNA ligase
The deposited structure of PDB entry 4hwr contains 2 copies of CATH domain 3.40.50.800 (Rossmann fold) in Threonine--tRNA ligase. Showing 1 copy in chain A.
3.30.930.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: BirA Bifunctional Protein; domain 2
Homology: Bira Bifunctional Protein; Domain 2
Occurring in:
  1. Threonine--tRNA ligase
The deposited structure of PDB entry 4hwr contains 2 copies of CATH domain 3.30.930.10 (BirA Bifunctional Protein; domain 2) in Threonine--tRNA ligase. Showing 1 copy in chain A.

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