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Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor

X-ray diffraction
1.7Å resolution
PDB entry 4i03 coloured by chain, front view.
PDB entry 4i03 coloured by chain, side view.
PDB entry 4i03 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8913.74 Å2
Buried surface area: 2592.55 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971

Macromolecules

Macrophage metalloelastase
Chain: A
Length: 159 amino acids
Theoretical weight: 17.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P39900 (Residues: 106-263; Coverage: 35%)
Gene names: HME, MMP12
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
Macrophage metalloelastase in PDB entry 4i03, assembly 1, front view.
Macrophage metalloelastase in PDB entry 4i03, assembly 1, side view.
Macrophage metalloelastase in PDB entry 4i03, assembly 1, top view.
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