› 4i1q

X-ray diffraction
2.53Å resolution

Crystal Structure of hBRAP1 N-BAR domain

Released:
DOI: 10.2210/pdb4i1q/pdb
PDB entry 4i1q coloured by chain, front view.
PDB entry 4i1q coloured by chain, side view.
PDB entry 4i1q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.
Sánchez-Barrena MJ, Vallis Y, Clatworthy MR, Doherty GJ, Veprintsev DB, Evans PR, McMahon HT
PLoS One 7 e52401 (2012)
PMID: 23285027

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193686 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bridging integrator 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 26.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBW5 (Residues: 20-238; Coverage: 39%)
Gene names: BIN2, BRAP1
Sequence domains: BAR domain
Structure domains: Arfaptin homology (AH) domain/BAR domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 79.147Å b: 81.278Å c: 81.101Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.252
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The life cycle of phagosomes: formation, maturation, and resolution.
Levin et al. (2016)
2 more

1 mention without citation

Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.
Sánchez-Barrena et al. (2012)