EC 1.1.1.88: Hydroxymethylglutaryl-CoA reductase
Reaction catalysed:
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH
Systematic name:
(R)-mevalonate:NAD(+) oxidoreductase (CoA-acylating)
Alternative Name(s):
- 3-hydroxy-3-methylglutaryl coenzyme A reductase
- Beta-hydroxy-beta-methylglutaryl CoA-reductase
- Beta-hydroxy-beta-methylglutaryl coenzyme A reductase
- HMG-CoA reductase
- Hydroxymethylglutaryl coenzyme A reductase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence family
Protein family (Pfam)
InterPro annotations
IPR023076
Domain description:
Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Occurring in:
Occurring in:
IPR023074
Domain description:
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
Occurring in:
Occurring in:
IPR009023
Domain description:
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
3.90.770.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homology:
3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Occurring in: