› › Structure analysis

Structure of human MHC class II protein HLA-DR1 carrying an influenza hemagglutinin peptide partially filling the binding groove

X-ray diffraction
2.12Å resolution
PDB entry 4i5b coloured by chain, front view.
PDB entry 4i5b coloured by chain, side view.
PDB entry 4i5b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 18354.89 Å2
Buried surface area: 7054.6 Å2
Dissociation area: 1,088.96 Å2
Dissociation energy (ΔGdiss): 18.08 kcal/mol
Dissociation entropy (TΔSdiss): 8.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135340
Assembly 2
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 19068.25 Å2
Buried surface area: 6996.02 Å2
Dissociation area: 1,045.76 Å2
Dissociation energy (ΔGdiss): 15.61 kcal/mol
Dissociation entropy (TΔSdiss): 7.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135340

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chains: A, D
Length: 187 amino acids
Theoretical weight: 21.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01903 (Residues: 27-213; Coverage: 82%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4i5b, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4i5b, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4i5b, assembly 1, top view.
Molecule details ›

Search similar proteins

HLA class II histocompatibility antigen, DRB1 beta chain
Chains: B, E
Length: 192 amino acids
Theoretical weight: 22.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01911 (Residues: 31-222; Coverage: 81%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 4i5b, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 4i5b, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 4i5b, assembly 1, top view.
Molecule details ›

Search similar proteins

truncated hemagglutinin peptide
Chains: C, F
Length: 12 amino acids
Theoretical weight: 1.35 KDa
truncated hemagglutinin peptide in PDB entry 4i5b, assembly 1, front view.
truncated hemagglutinin peptide in PDB entry 4i5b, assembly 1, side view.
truncated hemagglutinin peptide in PDB entry 4i5b, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links