Function and Biology Details
Reaction catalysed:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Signal transduction histidine kinase-related protein, C-terminal
- Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
- PAS domain
- Histidine kinase/HSP90-like ATPase
- Histidine kinase/HSP90-like ATPase superfamily
- Histidine kinase domain
- Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
- PAS fold
1 more domain
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
histidine kinase (preferred)
PDBe Complex ID:
PDB-CPX-184192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
histidine kinase
Molecule details ›
Chains: A, B
Length: 450 amino acids
Theoretical weight: 51.75 KDa
Source organism: Streptococcus mutans UA159
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 450 amino acids
Theoretical weight: 51.75 KDa
Source organism: Streptococcus mutans UA159
Expression system: Escherichia coli
UniProt:
- Canonical:
Q8DT64 (Residues: 1-450; Coverage: 100%)
Sequence domains:
- PAS fold
- His Kinase A (phospho-acceptor) domain
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL17U
Spacegroup:
P3121
Expression system: Escherichia coli
