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3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate

Source organism: Pseudomonas mevalonii
Biochemical function: hydroxymethylglutaryl-CoA reductase (NADH) activity
Biological process: coenzyme A metabolic process
Cellular component: peroxisomal membrane

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EC 1.1.1.88: Hydroxymethylglutaryl-CoA reductase

Reaction catalysed:
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH
Systematic name:
(R)-mevalonate:NAD(+) oxidoreductase (CoA-acylating)
Alternative Name(s):
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase
  • Beta-hydroxy-beta-methylglutaryl CoA-reductase
  • Beta-hydroxy-beta-methylglutaryl coenzyme A reductase
  • HMG-CoA reductase
  • Hydroxymethylglutaryl coenzyme A reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00368
Domain description: Hydroxymethylglutaryl-coenzyme A reductase
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
The deposited structure of PDB entry 4i6w contains 2 copies of Pfam domain PF00368 (Hydroxymethylglutaryl-coenzyme A reductase) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR023076
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR002202
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR023074
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR004553
Domain description: Hydroxymethylglutaryl-CoA reductase, bacterial-type
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR009023
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR009029
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Structure domains

CATH CATH domains
3.90.770.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homology: 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
The deposited structure of PDB entry 4i6w contains 2 copies of CATH domain 3.90.770.10 (3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Showing 1 copy in chain B.
3.30.70.420
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
The deposited structure of PDB entry 4i6w contains 2 copies of CATH domain 3.30.70.420 (Alpha-Beta Plaits) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Showing 1 copy in chain B.

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