› 4icu

X-ray diffraction
2.4Å resolution

Ubiquitin-like domain of human tubulin folding cofactor E - crystal from A

Released:
DOI: 10.2210/pdb4icu/pdb
PDB entry 4icu coloured by chain, front view.
PDB entry 4icu coloured by chain, side view.
PDB entry 4icu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism.
Serna M, Carranza G, Martín-Benito J, Janowski R, Canals A, Coll M, Zabala JC, Valpuesta JM
J Cell Sci 128 1824-34 (2015)
PMID: 25908846

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172414 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tubulin-specific chaperone E Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 85 amino acids
Theoretical weight: 9.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15813 (Residues: 443-527; Coverage: 16%)
Gene name: TBCE
Sequence domains: Ubiquitin-like domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 43.2Å b: 60.11Å c: 130.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.204 0.263
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Genetic causes of hypomagnesemia, a clinical overview.
Viering et al. (2017)
2 more