› 4if8

X-ray diffraction
2.08Å resolution

Structure Of Vaspin

Released:
DOI: 10.2210/pdb4if8/pdb
PDB entry 4if8 coloured by chain, front view.
PDB entry 4if8 coloured by chain, side view.
PDB entry 4if8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Vaspin inhibits kallikrein 7 by serpin mechanism.
Heiker JT, Klöting N, Kovacs P, Kuettner EB, Sträter N, Schultz S, Kern M, Stumvoll M, Blüher M, Beck-Sickinger AG
Cell Mol Life Sci 70 2569-83 (2013)
PMID: 23370777

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184883 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serpin A12 Chains: A, B
Molecule details ›
Chains: A, B
Length: 414 amino acids
Theoretical weight: 47.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IW75 (Residues: 22-414; Coverage: 100%)
Gene name: SERPINA12
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 133.55Å b: 152.1Å c: 61.45Å
α: 90° β: 97.52° γ: 90°
R-values:
R R work R free
0.197 0.197 0.221
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Adipokines in health and disease.
Fasshauer et al. (2015)
29 more

7 mentions without citation

Vaspin inhibits kallikrein 7 by serpin mechanism.
Heiker et al. (2013)
6 more