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Crystal structure of a human MAIT TCR in complex with bovine MR1

Source organisms:
Biochemical function: peptide antigen binding
Biological process: positive regulation of T cell activation
Cellular component: MHC class II protein complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. T cell receptor beta constant 1
  2. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
The deposited structure of PDB entry 4iiq contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in T cell receptor beta constant 1. Showing 1 copy in chain B.
The deposited structure of PDB entry 4iiq contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Beta-2-microglobulin. Showing 2 copies in chain C.

PF00129
Domain description: Class I Histocompatibility antigen, domains alpha 1 and 2
Occurring in:
  1. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
The deposited structure of PDB entry 4iiq contains 1 copy of Pfam domain PF00129 (Class I Histocompatibility antigen, domains alpha 1 and 2) in Beta-2-microglobulin. Showing 1 copy in chain C.

PF09291
Domain description: Domain of unknown function (DUF1968)
Occurring in:
  1. Ig-like domain-containing protein
The deposited structure of PDB entry 4iiq contains 1 copy of Pfam domain PF09291 (Domain of unknown function (DUF1968)) in Ig-like domain-containing protein. Showing 1 copy in chain A.

PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig-like domain-containing protein
The deposited structure of PDB entry 4iiq contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Ig-like domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. T cell receptor beta constant 1
  2. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Ig-like domain-containing protein
  2. T cell receptor beta constant 1
  3. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Ig-like domain-containing protein
  2. T cell receptor beta constant 1
  3. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Ig-like domain-containing protein
  2. T cell receptor beta constant 1
  3. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR001039
Domain description: MHC class I alpha chain, alpha1 alpha2 domains
Occurring in:
  1. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig-like domain-containing protein
  2. T cell receptor beta constant 1
IPR015370
Domain description: T-cell receptor alpha chain, constant domain
Occurring in:
  1. Ig-like domain-containing protein
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR015707
Domain description: Beta-2-Microglobulin
Occurring in:
  1. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Ig-like domain-containing protein
  2. T cell receptor beta constant 1
IPR011161
Domain description: MHC class I-like antigen recognition-like
Occurring in:
  1. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Ig-like domain-containing protein
  2. T cell receptor beta constant 1
  3. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
The deposited structure of PDB entry 4iiq contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 2 copies in chain A.
The deposited structure of PDB entry 4iiq contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T cell receptor beta constant 1. Showing 2 copies in chain B.
The deposited structure of PDB entry 4iiq contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-2-microglobulin. Showing 2 copies in chain C.
3.30.500.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homology: MHC class I-like antigen recognition-like
Occurring in:
  1. Beta-2-microglobulin; Major histocompatibility complex class I-related gene protein
The deposited structure of PDB entry 4iiq contains 1 copy of CATH domain 3.30.500.10 (Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1) in Beta-2-microglobulin. Showing 1 copy in chain C.

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