› 4im6

X-ray diffraction
1.65Å resolution

LRR domain from human NLRP1

Released:
DOI: 10.2210/pdb4im6/pdb
PDB entry 4im6 coloured by chain, front view.
PDB entry 4im6 coloured by chain, side view.
PDB entry 4im6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the leucine-rich repeat domain of the NOD-like receptor NLRP1: implications for binding of muramyl dipeptide.
Reubold TF, Hahne G, Wohlgemuth S, Eschenburg S
FEBS Lett 588 3327-32 (2014)
PMID: 25064844

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-189873 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 1, N-terminus Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 22.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9C000 (Residues: 791-990; Coverage: 14%)
Gene names: CARD7, DEFCAP, KIAA0926, NAC, NALP1, NLRP1
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P6122
Unit cell:
a: 84.69Å b: 84.69Å c: 130.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.137 0.134 0.183
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

The NLRP1 inflammasomes.
Chavarría-Smith et al. (2015)
14 more

8 mentions without citation

International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.
Bryant et al. (2015)
7 more