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Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-((5-(3-aminopropyl)-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)

Source organism: Rattus norvegicus
Biochemical function: nitric-oxide synthase activity
Biological process: nitric oxide biosynthetic process
Cellular component: not assigned

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EC 1.14.13.39: Nitric-oxide synthase (NADPH)

Reaction catalysed:
(1a) 2 L-arginine + 2 NADPH + 2 O(2) = 2 N(omega)-hydroxy-L-arginine + 2 NADP(+) + 2 H(2)O
Systematic name:
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Alternative Name(s):
  • Endothelium-derived relaxation factor-forming enzyme
  • Endothelium-derived relaxing factor synthase
  • NADPH-diaphorase
  • NO synthase
  • NOS (gene name)
  • Nitric oxide synthetase
  • Nitric-oxide synthetase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02898
Domain description: Nitric oxide synthase, oxygenase domain
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 4ims contains 2 copies of Pfam domain PF02898 (Nitric oxide synthase, oxygenase domain) in Nitric oxide synthase 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR004030
Domain description: Nitric oxide synthase, N-terminal
Occurring in:
  1. Nitric oxide synthase 1
IPR044944
Domain description: Nitric oxide synthase, domain 3 superfamily
Occurring in:
  1. Nitric oxide synthase 1
IPR044940
Domain description: Nitric oxide synthase, domain 2 superfamily
Occurring in:
  1. Nitric oxide synthase 1
IPR044943
Domain description: Nitric oxide synthase, domain 1 superfamily
Occurring in:
  1. Nitric oxide synthase 1
IPR036119
Domain description: Nitric oxide synthase, N-terminal domain superfamily
Occurring in:
  1. Nitric oxide synthase 1

Structure domains

CATH CATH domains
3.90.340.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nitric Oxide Synthase; Chain A, domain 1
Homology: Nitric Oxide Synthase; Chain A, domain 1
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 4ims contains 2 copies of CATH domain 3.90.340.10 (Nitric Oxide Synthase; Chain A, domain 1) in Nitric oxide synthase 1. Showing 1 copy in chain B.
3.90.440.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nitric Oxide Synthase;Heme Domain; Chain A, domain 2
Homology: Nitric Oxide Synthase;Heme Domain;Chain A domain 2
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 4ims contains 2 copies of CATH domain 3.90.440.10 (Nitric Oxide Synthase;Heme Domain; Chain A, domain 2) in Nitric oxide synthase 1. Showing 1 copy in chain B.
3.90.1230.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3
Homology: Nitric Oxide Synthase; Chain A, domain 3
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 4ims contains 2 copies of CATH domain 3.90.1230.10 (Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3) in Nitric oxide synthase 1. Showing 1 copy in chain B.

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