› 4iqh

X-ray diffraction
1.76Å resolution

Crystal Structure Analysis of Dysferlin C2A variant 1 (C2Av1)

Released:
DOI: 10.2210/pdb4iqh/pdb
PDB entry 4iqh coloured by chain, front view.
PDB entry 4iqh coloured by chain, side view.
PDB entry 4iqh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Alternate splicing of dysferlin C2A confers Ca²⁺-dependent and Ca²⁺-independent binding for membrane repair.
Fuson K, Rice A, Mahling R, Snow A, Nayak K, Shanbhogue P, Meyer AG, Redpath GM, Hinderliter A, Cooper ST, Sutton RB
Structure 22 104-15 (2014)
PMID: 24239457

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131173 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dysferlin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 130 amino acids
Theoretical weight: 14.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75923 (Residues: 1-19, 20-124; Coverage: 6%)
Gene names: DYSF, FER1L1
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 71.16Å b: 71.16Å c: 137.45Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.192 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Auditory neuropathy--neural and synaptic mechanisms.
Moser et al. (2016)
8 more

3 mentions without citation

Alternate splicing of dysferlin C2A confers Ca²⁺-dependent and Ca²⁺-independent binding for membrane repair.
Fuson et al. (2014)
2 more